Fig. 1
a Pathway analysis of RNA-seq data comparing 94 TNBCs vs. 20 normal breast tissues reveals the overexpression of the PI3K/AKT pathway. Statistical analysis revealed 3,197 genes (FDR < 5%, with a fold change more than ±2) that are differentially expressed between TNBC and normal (Supplementary Table 1). Significant genes were imported into ingenuity pathway analysis, revealing an active PI3K/AKT pathway. b The gene expression fold-changes and p-values of the differentially expressed components of the PI3K pathway in 1 a. c TCGA analysis using the cBioPortal database of 139 TNBC patients show that approximately 92% of individuals have an observed genomic aberration within the PI3K/AKT pathway. In this oncoprint plot, each row represents the stated gene, and each column is an individual patient. Colors representing each form of aberration are depicted below the plot
