Fig. 6
Lgr5 function is not required for mammary tumorigenesis. Four thousand EpCAMHIGH; CD49fHIGH; GFPPOS cells were harvested from Lgr5KIHET and Lgr5KIHOM; C3(1)Tag mice at E18 and injected into cleared recipient fat pads. Mice were euthanized at end point, which was when tumors reached 1 cm in diameter. a H and E stained sections of tumors harvested from mice transplanted with C3(1)Tag; Lgr5KIHET and C3(1)Tag; Lgr5KIHOM fMaSCs. Bar represents 50 µM. b Time to endpoint (tumors with a diameter of 1 cm) was compared between glands that were transplanted with Lgr5KIHOM or Lgr5KIHET; C3(1)Tag fMaSCs. Two mice reached end point due to Lgr5KIHET C3(1)Tag fMaSCs, both at 329 days. Three mice reached end point due to Lgr5KIHOM C3(1)Tag fMaSCs, at an average of 300 days (+/− 45 days)
