Fig. 4
The induction of ZNF423 and BRCA1 mRNA expression in a SNP-dependent, SERM-dependent fashion for LCLs homozygous for WT and variant ZNF423 rs746157 and rs12918288 genotypes. a The figure shows the effect of E2 and E2 plus 4OH-TAM dose response curves on the expression for ZNF423 and BRCA1 in LCLs homozygous for WT and variant genotypes for the rs746157 and rs12918280 SNPs in ZNF423 intron 5. Values are mean ± SEM for 3 determinations. All of these LCLs were homozygous WT for the intron 2 rs9940645 SNP. b Bar graphs showing mRNA expression for ZNF423 and BRCA1 at the optimal concentrations for E2 (0.01 nM) and E2 (0.01 nM) plus 4OH-TAM (0.01 μM) shown in (a). Compare with Fig. 1b. Data represented as mean ± SEM
