Fig. 5
From: Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer
GSEA analysis identifies DNA repair after ionizing radiation as a top concept associated with AR expression (a). AR inhibition through with MDV3100 significantly delays double stranded DNA break repair at 2, 6, and 16 h in the AR-positive TNBC cell lines MDA-MB-453 (b) and ACC-422 (c) but not the AR-negative TNBC cell line MDA-MB-231 (d). Cells were treated with MDV3100, RT, or combination and γH2AX foci were manually counted. Images are representative of cells are the indicated time points. Minimum of 100 cells per condition were counted, and experiments were repeated in triplicate. Error bars represent SD
