Fig. 4 | npj Breast Cancer

Fig. 4

From: Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways

Fig. 4

Proposed model of the evolutionary origin of borderline and malignant phyllodes tumors. Phyllodes tumors might follow two different evolutionary pathways. (i) In the MED12-mutant pathway, MED12 exon 2 mutations are posited to lead to the development of a benign fibroepithelial lesion, which upon the occurrence of additional genetic alterations affecting TERT and/ or other cancer genes may progress to a borderline or malignant phyllodes tumor. (ii) In the MED12-independent pathway, borderline or malignant phyllodes tumors might arise de novo, through the acquisition of genetic alterations targeting cancer genes, such as TERT and/ or EGFR. TSG tumor suppresor genes

Back to article page