Table 2 Multivariable analysis of factors that impacted recommendation for adjuvant chemotherapy stratified by RS testing result

From: Use of 21-gene recurrence score assay to individualize adjuvant chemotherapy recommendations in ER+/HER2− node positive breast cancer—A National Cancer Database study

 

Low < 18

Intermediate 18–25

Intermediate 26–30

Variable

Odds ratio (95% CI)

P-value

Odds ratio (95% CI)

P-value

Odds ratio (95% CI)

P-value

Age category

 

Overall trend p < 0.001

 

Overall trend p < 0.001

 

Overall trend p < 0.001

<40

3.13 (2.22, 4.41)

<0.001

3.62 (1.90, 6.88)

<0.001

5.20 (0.31, 87.74)

0.25

40–49

1.71 (1.49, 1.97)

<0.001

1.84 (1.43, 2.36)

<0.001

1.86 (0.74, 4.69)

0.19

50–59

1.0 reference

 

1.0 reference

 

1.0 reference

 

60–69

0.68 (0.60, 0.77)

<0.001

0.66 (0.55, 0.80)

<0.001

0.44 (0.24, 0.81)

0.008

70–79

0.37 (0.31, 0.43)

<0.001

0.31 (0.25, 0.40)

<0.001

0.14 (0.07, 0.26)

<0.001

80+

0.18 (0.12, 0.29)

<0.001

0.10 (0.06, 0.18)

<0.001

0.08 (0.03, 0.23)

<0.001

Charlson–Deyo score

 

Overall trend p = 0.91

 

Overall trend p = 0.008

 

Overall trend p = 0.83

0

1.0 reference

 

1.0 reference

 

1.0 reference

 

1

0.95 (0.82, 1.10)

0.50

0.78 (0.62, 0.97)

0.02

1.16 (0.63, 2.15)

0.63

2+

1.03 (0.76, 1.39)

0.86

0.69 (0.42, 1.16)

0.16

0.66 (0.25, 1.78)

0.41

Pathologic T stage

 

Overall trend p < 0.001

 

Overall trend p = 0.06

 

Overall trend p = 0.12

T1

1.0 reference

 

1.0 reference

 

1.0 reference

 

T2

1.33 (1.19, 1.48)

<0.001

1.17 (0.99, 1.38)

0.08

1.27 (0.81, 1.99)

0.30

T3/T4 a-c

2.16 (1.61, 2.89)

<0.001

1.34 (0.81, 2.23)

0.26

3.87 (0.53, 28.33)

0.18

Pathologic N stage

 

Overall trend p < 0.001

 

Overall trend p < 0.001

 

Overall trend p = 0.49

N1mi

1.0 reference

 

1.0 reference

 

1.0 reference

 

N1

2.25 (2.01, 2.52)

<0.001

1.38 (1.17, 1.63)

<0.001

1.18 (0.74, 1.88)

0.50

N2+

8.93 (6.61, 12.07)

<0.001

3.67 (2.06, 6.54)

<0.001

0.86 (0.22, 3.28)

0.82

Grade

 

Overall trend p < 0.001

 

Overall trend p < 0.001

 

Overall trend p = 0.23

Well differentiated

1.0 reference

 

1.0 reference

 

1.0 reference

 

Moderately differentiated

1.17 (1.05, 1.32)

0.005

1.48 (1.23, 1.79)

<0.001

1.36 (0.71, 2.62)

0.35

Poorly differentiated/Undifferentiated

1.63 (1.34, 1.98)

<0.001

2.27 (1.75, 2.95)

<0.001

1.61 (0.80, 3.25)

0.18

Cell type undetermined

1.07 (0.84, 1.37)

0.60

1.40 (0.96, 2.05)

0.08

0.53 (0.18, 1.54)

0.24

ILC histology

      

Yes

1.0 reference

 

1.0 reference

 

1.0 reference

 

No

1.08 (0.93, 1.26)

0.30

0.94 (0.74, 1.19)

0.60

0.86 (0.39, 1.88)

0.70

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