Table 2 Associations between selected characteristics and mammographic density based on polytomous logistic regression in Chinese Breast Cancer Screening Program

From: Breast cancer risk factors and mammographic density among high-risk women in urban China

 

BI-RADS 2 vs. 1

BI-RADS 3 vs. 1

BI-RADS 4 vs. 1

ORtrend (95% CI)b

P trend b

 

OR (95% CI)a

OR (95% CI)a

OR (95% CI)a

Age

Per 2 years

0.84 (0.82–0.87)

0.70 (0.68–0.72)

0.64 (0.60–0.68)

0.80 (0.79–0.82)

<1.0E-30

Family history of breast and ovarian cancers

1st or 2nd degree relativesc

1.06 (0.87–1.29)

1.07 (0.87–1.32)

1.28 (0.89–1.84)

1.05 (0.94–1.16)

0.02

1st degree relatives with breast cancer <50 years

0.85 (0.71–1.00)

0.80 (0.67–0.96)

0.61 (0.43–0.87)

0.87 (0.80–0.96)

4.6E-04

Education

Middle school vs. none-elementary

1.62 (1.33–1.98)

2.13 (1.71–2.67)

2.08 (1.18–3.66)

1.61 (1.41–1.83)

1.4E-12

High school vs. none-elementary

2.00 (1.62–2.47)

2.85 (2.26–3.59)

3.72 (2.15–6.42)

1.84 (1.61–2.10)

1.1E-19

College +vs. none-elementary

2.40 (1.86–3.11)

4.44 (3.36–5.86)

6.41 (3.59–11.45)

2.34 (2.03–2.71)

<1.0E-30

Body mass index

Per 2 kg/m2

0.78 (0.74–0.81)

0.66 (0.63–0.69)

0.44 (0.40–0.49)

0.78 (0.76–0.80)

<1.0E-30

Heightd

Per 2 cm

1.13 (1.09–1.17)

1.19 (1.15–1.24)

1.33 (1.24–1.43)

1.10 (1.08–1.12)

1.1E-23

Weightd

Per 2 kg

0.91 (0.89–0.93)

0.85 (0.83–0.87)

0.73 (0.70–0.76)

0.91 (0.90–0.92)

<1.0E-30

Age at menarche

13-14 vs. <13

1.14 (0.88–1.48)

1.07 (0.82–1.40)

0.91 (0.60–1.38)

0.96 (0.85–1.10)

0.56

15 + vs. <13

1.07 (0.83–1.39)

0.95 (0.73–1.25)

0.74 (0.47–1.16)

0.90 (0.79–1.03)

0.13

Parity

Parous vs. nulliparous

0.67 (0.46–0.98)

0.58 (0.39–0.86)

0.34 (0.20–0.59)

0.74 (0.62–0.88)

4.9E-04

Age at first full term birthe

25–26 vs. <25

1.37 (1.14–1.66)

1.45(1.19–1.78)

1.47 (1.02–2.12)

1.17 (1.06–1.30)

2.2E-03

27–28 vs. <25

1.32 (1.06–1.64)

1.50 (1.19–1.89)

1.49 (0.96–2.30)

1.22 (1.08–1.37)

9.3E-04

29+ vs. <25

1.55 (1.21–1.99)

1.89 (1.46–2.45)

2.09 (1.31–3.33)

1.38 (1.21–1.57)

1.2E-06

Breastfeedinge

1–6 months vs. no breastfeeding

1.42 (1.08–1.85)

1.40 (1.06–1.85)

1.26 (0.80–1.99)

1.07 (0.94–1.23)

0.31

7–12 months vs. no breastfeeding

1.30 (1.04–1.64)

1.38 (1.08–1.74)

1.21 (0.81–1.81)

1.12 (0.99–1.25)

0.07

13 months+ vs. no breastfeeding

0.99 (0.78–1.26)

0.87 (0.68–1.13)

0.45 (0.27–0.75)

0.84 (0.74–0.96)

0.01

Menopausal status

Postmenopausal vs. Premenopausal

0.73 (0.58–0.92)

0.55 (0.44–0.70)

0.40 (0.28–0.59)

0.73 (0.66–0.81)

3.5E-09

  1. aPolytomous logistic regression was used to estimate ORs and 95% CIs comparing each of the higher BI-RADS categories (2, 3, 4) to BI-RADS = 1, adjusted for province, age, family history, education, BMI, age at menarche, parity, and menopausal status
  2. bCumulative logistic regression (CLOGIT function) and Wald χ2 test were used to estimate ORtrend and Ptrend, with MD modeled as an ordinal variable comparing higher to lower BI-RADS categories (with BI-RADS = 1 as the reference). Model was adjusted for the same factors as above
  3. cExcluding women with first-degree relatieves with breast cancer <50 years
  4. dBMI was replaced with height and weight in the model
  5. eParous women only. Model was adjusted for province, age, family history, education, BMI, age at menarche, age at first full term birth, breastfeeding, and menopausal status
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