Fig. 6 | npj Breast Cancer

Fig. 6

From: Genomic and expression profiling reveal molecular heterogeneity of disseminated tumor cells in bone marrow of early breast cancer

Fig. 6

DTCs and CTCs exhibit expression profiles that are unique from each other. a Unsupervised hierarchical clustering analysis of CTCs (n = 105) and DTCs (n = 30) along with matched blood leukocytes (n = 76) and marrow leukocytes (n = 15). b t-SNE analysis to determine clusters based on similarities in gene expression. c A rose plot showing genes upregulated in DTCs and CTCs. Genes with an adjusted p-value < 0.05 were considered statistically significant. Relative quantification (RQ) is reported in the logarithmic scale (log10 RQ = log10^2-∆∆CT). A Log10 RQ = 1 or −1 means a gene is expressed 10 times or 1/10 as much, respectively

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