Fig. 2
GE analysis of PDS and PDR cells. a Heatmap showing the top 15 most variable cell cycle pathway genes (rows) between PDR and PDS treated cells (columns). Values are the log2 of Fold Change (FC) of normalized expression in each cell lines with respect to the corresponding PDS. The different cell models are reported in the annotation track (PDS treated, PDR early, PDR late). b Box plot showing the distribution of RBsig score across the different cell models. c Combined Gene Set Enrichment Analysis (GSEA) plot of PDS treated (gray lines) and PDR (black lines) using averaged FC as ranking parameters and E2F targets as gene set. For both PDS treated and PDR, FDR ~ 0. d Averaged FC in PDR (y-axis) versus averaged FC in PDS treated for E2F target genes. The top five genes having the greatest absolute difference in FC between PDR and PDS treated models are shown. e Box plot showing the distribution of FC of CCNE1 expression in PDS treated and PDR models. **P-value < 0.01, ***P-value < 0.001; by Wilcoxon test
