Fig. 3 | npj Breast Cancer

Fig. 3

From: NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients

Fig. 3

NDRG4 methylation is associated with overall survival (OS, TCGA cohort) and poor distant-metastasis free survival (DMFS, ACC cohort) in patients with breast cancer. a Kaplan–Meier analysis based on NDRG4 methylation levels for cg01466678 (NDRG4 promoter CpG island) by using MethSurv web tool (training cohort). p = 0.0085 by log-rank test. b Kaplan–Meier analysis based on NDRG4 DNA hypermethylation status by nested-MSP in a total of 61 ACC patient’s cohort (validation cohort) (methylated group n = 10, unmethylated group n = 51). p = 0.001 by log-rank test

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