Table 2 Adverse events occurring in ≥10% of patients on study treatment
Letrozole + Dasatinib (N = 57) | Letrozole (N = 63) | |||||||
|---|---|---|---|---|---|---|---|---|
Adverse Event | Grade 1 (n (%)) | Grade 2 (n (%)) | Grade 3 (n (%)) | Total (n (%)) | Grade 1 (n (%)) | Grade 2 (n (%)) | Grade 3 (n (%)) | Total (n (%)) |
Rash | 8 (14) | 5 (9) | 2 (4) | 15 (26) | 0 | 0 | 0 | 0 |
Edema | 1 (2) | 4 (7) | 2 (4) | 7 (12) | 0 | 0 | 0 | 0 |
Fatigue | 15 (26) | 8 (14) | 1 (2) | 24 (42) | 3 (5) | 2 (3) | 0 | 5 (8) |
Anemia | 10 (18) | 3 (5) | 1 (2) | 14 (25) | 0 | 0 | 0 | 0 |
Neutropenia | 7 (12) | 5 (9) | 1 (2) | 13 (23) | 0 | 0 | 0 | 0 |
Arthralgia | 6 (11) | 2 (4) | 1 (2) | 9 (15) | 1 (2) | 2 (3) | 0 | 3 (5) |
Pleural Effusion | 4 (7) | 4 (7) | 1 (2) | 9 (16) | 0 | 0 | 0 | 0 |
Hot Flashes | 7 (12) | 1 (2) | 0 | 8 (14) | 10 (16) | 2 (3) | 1 (2) | 13 (20) |
Nausea | 15 (26) | 7 (12) | 0 | 22 (39) | 5 (8) | 0 | 0 | 5 (8) |
Diarrhea | 7 (12) | 3 (5) | 0 | 10 (18) | 0 | 0 | 0 | 0 |
Vomiting | 5 (9) | 3 (5) | 0 | 8 (14) | 0 | 0 | 0 | 0 |
Headache | 5 (9) | 2 (4) | 0 | 7 (12) | 2 (3) | 0 | 0 | 2 (3) |
Pain | 4 (7) | 1 (2) | 0 | 5 (9) | 4 (6) | 4 (6) | 0 | 8 (13) |
