Table 3 Summary of top 10 ranked histologic features identified in the random forest model for the prediction of invasive cancer status among women with high and low % fibroglandular volume
Feature Name | High global FGV (%) (> median) | Low global FGV (%) (≤ median) | High localized FGV (%) (> median) | Low localized FGV (%) (≤ median) |
|---|---|---|---|---|
Global tissue amount | ||||
Fat amount (µm2) | − | 8 | − | 5 |
Fat amount normalized (%) | − | 3 | − | 7 |
Stroma amount (µm2) | − | 9 | − | − |
Stroma amount normalized (%) | − | 4 | 10 | 3 |
Epithelium amount (µm2) | 4 | − | 4 | 1 |
Epithelium amount normalized (%) | 6 | − | 7 | 8 |
Morphology | ||||
Epithelial regions (IQ µm2) | − | − | 1 | 4 |
Epithelial regions (max µm2) | 9 | − | − | − |
Ecc epi regions (mean) | 10 | − | 3 | 9 |
Ecc epi regions (median) | − | − | 2 | 2 |
Ecc epi regions (IQ) | − | − | 5 | 10 |
Spatial arrangement of the epithelial regions (Area-Voronoi diagram) | ||||
Voronoi area (mean µm2) | 5 | 7 | 6 | − |
Voronoi area (median µm2) | 3 | 5 | − | − |
Voronoi area (SD µm2) | − | − | 9 | − |
Voronoi area (IQ µm2) | 7 | 6 | − | − |
Ratio epi to Voronoi (mean) | 1 | 2 | 8 | − |
Ratio epi to Voronoi (median) | 2 | 1 | − | − |
Ratio epi to Voronoi (IQ) | − | 10 | − | − |
Ratio epi to non-epi (median) | 6 | |||
Spatial arrangement of the epithelial regions (Delaunay Triangulation) | ||||
Neighbors (mean number) | 8 | − | − | − |
