Table 4 Risk of all-causes mortality stratified by follow-up time of breast cancer survivors across tertiles of post-diagnosis E-DII from food plus supplement in the PLCO Cancer Screening Trial.

	E-DII tertile 1 (−7.8, −5.6)	E-DII tertile 2 (−5.6, −4.1)	E-DII tertile 3 (−4.1, 4.9)	P_trend	P_interaction^a
≤15 person-years, (n)	180	172	216		<0.001
Death from any cause (n)	70	79	93
Age and energy-adjusted HR (95% CI)	1.00 (reference)	1.19 [0.87, 1.65]	1.27 [0.93, 1.73]	0.14
Multivariable-adjusted HR (95% CI)^b	1.00 (reference)	1.21 [0.87, 1.69]	1.25 [0.91, 1.72]	0.18
>15 person-years (n)	175	182	139
Death from any cause (n)	16	19	19
Age and energy-adjusted HR (95% CI)	1.00 (reference)	1.29 [0.66, 2.52]	2.06 [1.05, 4.05]	0.04
Multivariable-adjusted HR (95% CI)^b	1.00 (reference)	1.24 [0.61, 2.54]	2.18 [1.03, 4.64]	0.04

^aP_interaction was calculated by adding the cross-product of quartile E-DII and the follow-up time (≤15 person years and >15 person-years) in the COX proportional hazards regression model.
^bStratified by age of breast cancer diagnosis (≤60 years old, >60 years old), years from breast cancer diagnosis to DHQ completion (≤1 year, >1 year), stage (0/I, II/III) due to PH assumption violation and adjusted for total energy intake (continues, kcal/day), body mass index (continues, kg/m2), trial arm (control, intervention), race (white, black, others), marital status (single, married, divorced or separated, widowed), income(<$20,000, $20,000–$49,000, $50,000–$99,000, $100,000–$200,000, <$200,000), educational level (less than high school, high school graduate or equivalent, post-high school education, college education or higher), smoking status (never smoked, past smoked, current smoked), hormone replacement therapy (never used, former used, current used), history of diabetes (no, yes), physical activity (active less than one time per month, active at least one time per month), estrogen receptor status (negative, positive), and progesterone receptor status (negative, positive).

Quick links

Search