Fig. 4: Gene expression profiles of HER2-negative breast cancer according to HER2 expression and HR status.
From: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer
Supervised clustering of 55 genes across four tumor classes defined according to HER2 IHC expression and HR status. All samples and gene expression data in each category have been combined into a single group. For each gene in a group, we calculated the standardized mean difference between the gene’s expression in that class vs. its overall mean expression in the dataset using a 4-class Significance Analyses of Microarrays. The red color represents relative high gene score, green represents relative low gene score, and black represents median gene score. HR-positive hormone receptor positive, TNBC triple-negative breast cancer.
