Table 1 Population characteristics according to HER2 status.

From: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Demographics	HER2-negative						p^a
	HER2 0		HER2-low		Overall population
	N	%	N	%	N	%
	1,486	40.3	2,203	59.7	3,689	100
Age at diagnosis (years)
Median	55		59		58		0.003
IQR	46–65		49–67		48–67
Min–max	24–93		26–96		24–96
Pts with available data	259	27.4	685	72.6	944	100
Sex
Male	0	0	15	0.7	15	0.4	0.001
Female	1,486	100	2,187	99.3	3,673	99.6
Total	1,486	40.3	2,202	59.7	3,688	100
Menopaual status
Pre/perimenopausal	385	37.3	660	37.1	1,045	37.2	0.898
Postmenopausal	646	62.7	1,119	62.9	1,765	62.8
Total	1,031	36.7	1,779	63.3	2,810	100
Biospecimen
Primary lesion	1,000	73.7	1,382	71.1	2,382	72.1	0.096
Other lesion	357	34.6	563	28.9	920	27.9
Total	1,357	41.1	1,945	58.9	3,302	100
Histotype
Ductal	639	70.8	1,214	74.3	1,853	73	0.175
Lobular	194	21.5	314	19.2	508	20
Other	69	7.6	107	6.5	176	6.9
Total	902	35.6	1,635	64.4	2,537	100
T
1	509	55.8	807	48.7	1,316	51.2	0.007
2	294	32.2	618	37.3	912	35.5
3	71	7.8	142	8.6	213	8.3
4	38	4.2	89	5.4	127	4.9
Total	912	35.5	1,656	64.5	2,568	100
N
0	556	58.8	937	55.6	1,493	56.8	0.01
1	272	28.8	464	27.6	736	28
2	71	7.5	148	8.8	219	8.3
3	46	4.9	135	8	181	6.9
Total	945	35.9	1,684	64.1	2,629	100
ER
Positive	983	67	1,894	87.1	2,877	79	<0.001
Negative	484	33	280	12.9	764	21
Total	1,467	40.3	2,174	59.7	3,641	100
PgR
Positive	789	54.7	1,542	71.8	2,331	64.9	<0.001
Negative	654	45.3	606	28.2	1260	35.1
Total	1,443	40.2	2,148	59.8	3,591	100
G
1	67	8.8	139	10.6	206	9.9	0.0499
2	272	35.6	514	39.1	786	37.8
3	426	55.7	660	50.3	1086	52.3
Total	765	36.8	1,313	63.2	2,078	100
Ki67
Median	16		18		18		0.892
IQR	9–30		10–27		10–27
Min–max	0.5–95		0.5–95		0.5–95
Pts with available data	433	36.4	756	63.6	1,189	100
≤14%	190	43.9	294	38.9	484	40.7	0.092
>14%	243	56.1	462	61.1	705	59.3	0.092
<20%	236	54.5	411	54.4	647	54.4	0.963
≥20%	197	45.5	345	45.6	542	45.6	0.963
TILs
Median	1		1		1		0.218
IQR	0–5		1–5		1–5
Min–max	0–80		0–80		0–80
Pts with available data	102	37.2	172	62.8	274	100
PAM50 subtypes
Luminal A	193	28.7	459	50.8	652	41.4	<0.001
Luminal B	127	18.9	260	28.8	387	24.6
HER2-enriched	40	5.9	32	3.5	72	4.6
Basal-like	294	43.7	120	13.3	414	26.3
Normal-like	19	2.8	32	3.5	51	3.1
Total	673	42.7	903	57.3	1,576	100
HR status
HR-positive	1,025	69.6	1,937	88.2	2,962	80.8	<0.001
TNBC	448	30.4	258	11.8	706	19.2
Total	1,473	40.2	2195	59.8	3,668	100

^aChi-square test for differences in proportions, Kruskalis–Wallis and Wilcoxon rank sum test with continuity correction, where appropriate, for continuous variables (median comparisons).
Pts patients, HR hormone receptors, IQR interquartile range, IHC immunohistochemical, TILs tumor-infiltrating lymphocytes.

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Table 1 Population characteristics according to HER2 status.

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