Table 3 Intrinsic subtypes distribution in HER2-low tumors according to ERBB2 mRNA levels.

From: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

Intrinsic subtype

ERBB2 high (T3-T2)

ERBB2 low (T1)

HER2-low

pa

pb

pc

N

%

N

%

N

%

Luminal A

140

51.5

44

31.7

184

44.8

<0.001

<0.001

<0.001

Luminal B

95

34.9

22

15.8

117

28.5

HER2-enriched

17

6.3

5

3.6

22

5.4

Basal-like

8

2.9

62

44.6

70

17.0

Normal-like

12

4.4

6

4.3

18

4.4

Total

272

66.2

139

33.8

411

100.0

  1. ERBB2 is italicized, as per standard gene ID formatting guidelines. T1: tertile one; T2: tertile two; T3: tertile 3.
  2. aReferred to the comparison between ERBB2 high vs. low.
  3. bReferred to ERBB2 high vs. the overall HER2-low population.
  4. cReferred to ERBB2 low vs. the overall HER2-low population.
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