Table 4 Top 20 differentially expressed genes between HER2-low and HER2 0 disease.
From: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer
Gene symbol | Association | Overall | HR-positive | TNBC | |||
|---|---|---|---|---|---|---|---|
Score(d) (strength of relationship) | FDRa | Score(d) (strength of relationship) | FDRa | Score(d) (strength of relationship) | FDRa | ||
ESR1 | Higher in HER2-low | 14.3 | 0 | 5.0 | 0 | 1.0 | 100 |
FOXA1 | Higher in HER2-low | 13.3 | 0 | 4.9 | 0 | 1.0 | 100 |
NAT1 | Higher in HER2-low | 12.3 | 0 | 4.1 | 0 | −0.3 | 68.3 |
SLC39A6 | Higher in HER2-low | 11.6 | 0 | 4.0 | 0 | −0.4 | 64.3 |
PGR | Higher in HER2-low | 11.2 | 0 | 3.2 | 0 | 0.5 | 100 |
AR | Higher in HER2-low | 10.6 | 0 | — | — | 0.4 | 100 |
ERBB2 | Higher in HER2-low | 10.0 | 0 | 5.2 | 0 | 1.7 | 100 |
MAPT | Higher in HER2-low | 9.9 | 0 | 2.9 | 0 | −0.2 | 68.3 |
MLPH | Higher in HER2-low | 8.8 | 0 | 2.6 | 0 | 0.0 | 68.3 |
BCL2 | Higher in HER2-low | 8.2 | 0 | 2.5 | 0 | 0.0 | 68.3 |
CENPF | Lower in HER2-low | −7.0 | 0 | −1.8 | 0 | −1.0 | 64.3 |
EXO1 | Lower in HER2-low | −7.1 | 0 | −2.4 | 0 | −1.2 | 64.3 |
ANLN | Lower in HER2-low | −7.4 | 0 | −2.3 | 0 | −0.4 | 64.3 |
ORC6L | Lower in HER2-low | −7.6 | 0 | −2.3 | 0 | −0.8 | 64.3 |
KNTC2 | Lower in HER2-low | −7.8 | 0 | −2.3 | 0 | −0.7 | 64.3 |
CEP55 | Lower in HER2-low | −7.8 | 0 | −1.3 | 3.2 | −1.1 | 64.3 |
PHGDH | Lower in HER2-low | −8.4 | 0 | −1.7 | 0 | −1.2 | 64.3 |
FOXC1 | Lower in HER2-low | −8.4 | 0 | −0.7 | 9.7 | 0.2 | 100 |
MKI67 | Lower in HER2-low | −8.7 | 0 | −2.4 | 0 | −1.0 | 64.3 |
CCNE1 | Lower in HER2-low | −9.6 | 0 | −3.0 | 0 | −0.9 | 64.3 |
