Table 4 Odds ratios for TNBC versus breast cancer of other subtypes for patients with pathogenic variants in BRCA1, BRCA2, or PALB2a.

From: Inherited predisposition to breast cancer in the Carolina Breast Cancer Study

Gene

TNBC

Not TNBC

OR (95% CI)

P-value

African-American patients

BRCA1

4 (0.022)

2 (0.006)

3.78 (0.69, 20.9)

0.19b

BRCA2

8 (0.045)

5 (0.015)

3.15 (1.01, 9.79)

0.04

PALB2

4 (0.022)

3 (0.009)

2.63 (0.58, 11.9)

0.24

BRCA2 or PALB2

12 (0.067)

8 (0.024)

2.95 (1.18, 7.37)

0.018

Total

178 (1.000)

331 (1.000)

  

European-American patients

BRCA1

7 (0.055)

6 (0.012)

5.36 (1.77, 16.2)

0.004b

BRCA2

3 (0.024)

15 (0.027)

0.90 (0.26, 3.17)

ns

PALB2

0

7 (0.013)

0

ns

BRCA2 or PALB2

3 (0.024)

22 (0.039)

0.62 (0.18, 2.09)

ns

Total

127 (1.000)

557 (1.000)

  
  1. OR odds ratio, CI confidence interval, P P-value.
  2. aTNBC status could be assigned for 86% (509/591) of tumors of African-American patients and 90% (684/760) of tumors of European-American patients.
  3. bLog-linear analysis for all patients of BRCA1 genotype × TNBC status × ancestry yields P = 0.0045 for the BRCA1-TNBC association, controlling for ancestry.
Back to article page