Table 1 Comparison of intraclass correlation coefficient and pair-wise observer concordance rate for 3 ring studies.

From: Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

 

Ring study 1

Ring study 2

Ring study 3

ICC

0.7 (0.62–0.78)

0.89 (0.85–0.92)

0.76 (0.69–0.83)

Concordance ratesa

TILs <1 vs ≥1%

0.94 (±0.08)

0.94 (±0.04)

0.91 (±0.06)

TILs <5 vs ≥5%

0.83 (±0.09)

0.89 (±0.05)

0.84 (±0.1)

TILs <10 vs ≥10%

0.77 (±0.08)

0.86 (±0.05)

0.79 (±0.06)

TILs <30 vs ≥30%

0.81 (±0.08)

0.93 (±0.03)

0.87 (±0.04)

TILs <75 vs ≥75%

0.90 (±0.06)

0.92 (±0.03)

0.94 (±0.03)

  1. ICC intraclass correlation coefficient, TILs tumor-infiltrating lymphocytes.
  2. aThe concordance of all pairs of pathologists was calculated for five different TIL-groups. The values in the table are the sample mean and sample standard deviation of these concordance rates for all pairs of pathologists in each study.