Fig. 3: Enrichment of immune cell subpopulations in AA and EA patients with BasalMyo breast tumors. | npj Breast Cancer

Fig. 3: Enrichment of immune cell subpopulations in AA and EA patients with BasalMyo breast tumors.

From: Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry

Fig. 3

a. Enrichment scores of signatures reflecting the abundance of dendritic cells (DCs), T-regulatory cells (Tregs), T-helper 2 (Th2), and B cells in BasalMyo tumor samples of EA and AA patients. Box plots are facetted by ICR groups, ICR high (upper panels), ICR medium + low (middle panels), and across all samples (lower panels). Box plots indicate medians and interquartile range, and whiskers represent 10th and 90th percentile. All data points are plotted individually. T test (two-sided): *p < 0.05, **p < 0.01, ***p < 0.001, and n.s. not significant. Adjusted p value (FDR) by Benjamini and Hochberg method. b Kaplan–Meier plots of overall survival in EA and AA patients with BasalMyo breast cancer dichotomized by enrichment scores of TReg (left panels) and Th2 cell signatures (right panels). Cutoff for dichotomization in “High” and “Low” categories is based on optimal enrichment cutoff determined by XGBoost model used for survival analysis. Censor points are indicated by vertical lines.

Back to article page