Fig. 1: PRISMA flow diagram.

Search queries were conducted in PubMed, EMBASE, and CENTRAL from their inception to 25 March 2020 for randomized controlled trials investigating trastuzumab that reported incidence of intracranial metastatic disease42.
Search queries were conducted in PubMed, EMBASE, and CENTRAL from their inception to 25 March 2020 for randomized controlled trials investigating trastuzumab that reported incidence of intracranial metastatic disease42.