Fig. 6: Neutrophil degranulation and 48 ‘core proteins’ are conserved in lymph node (LN) metastasis, across cancers.
From: Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment
Concurrent comparison of the REPLICANT proteome to node-positive pancreatic and node-positive prostate adenocarcinoma identified 438 commonly expressed proteins. Pathway analysis of these 438 proteins is shown in A. ‘Neutrophil degranulation’ once again was identified as being important to LN metastasis. Certain protein families were also seen to recur across the three datasets (48 ‘core proteins’). Pathway analysis of these ‘core proteins’ is shown in B.
