Fig. 5: hPRLrL + I heterodimer signal transduction. | npj Breast Cancer

Fig. 5: hPRLrL + I heterodimer signal transduction.

From: The human intermediate prolactin receptor is a mammary proto-oncogene

Fig. 5

MCF10AT transfectants were PRL (250 ng/mL) stimulated for 0, 15, and 30 min, and phospho-IB was utilized to assess the activation status of a, b Jak2/Stat5a and c, d Mek/Erk. Band intensities were quantified using densitometry. Significance was determined by comparing each condition to the MCF10AT-EV negative control for each respective time point. *p < 0.05, n = 3.

Back to article page