TABLE 2 Oncotype DX Breast Recurrence Score® results categorized according to RS groups used prior to TAILORx (left) and RS groups based on TAILORx cut points (shaded columns, right).
From: PONDx: real-life utilization and decision impact of the 21-gene assay on clinical practice in Italy
RS categories as defined prior to TAILORx | RS categories based on TAILORx cut points | ||||
|---|---|---|---|---|---|
0–17 | 18–30 | 31–100 | 0–25 | 26–100 | |
Overall population (N = 1738) | 987 (57%) | 588 (34%) | 163 (9%) | 1444 (83%) | 294 (17%) |
Histological grade | |||||
G1 (n = 165) | 123 (75%) | 41 (25%) | 0 (0%) | 164 (99%) | 1 (1%) |
G2 (n = 1090) | 684 (63%) | 351 (32%) | 196 (5%) | 969 (89%) | 121 (11%) |
G3 (n = 483) | 179 (37%) | 196 (41%) | 108 (22%) | 311 (64%) | 172 (36%) |
Tumor size | |||||
<1 cm (n = 232) | 144 (62%) | 74 (32%) | 14 (6%) | 195 (84%) | 37 (16%) |
1–2 cm (n = 1052) | 589 (56%) | 369 (35%) | 94 (9%) | 888 (84%) | 164 (16%) |
2.1–5 cm (n = 432) | 240 (56%) | 138 (32%) | 54 (13%) | 343 (79%) | 89 (21%) |
>5.0 cm (n = 22) | 14 (64%) | 7 (32%) | 1 (5%) | 18 (82%) | 4 (18%) |
Nodal status | |||||
N0 (n = 1192) | 644 (54%) | 417 (35%) | 131 (11%) | 959 (80%) | 233 (20%) |
Nmic (n = 113) | 61 (54%) | 44 (39%) | 8 (7%) | 97 (86%) | 16 (14%) |
N1 (n = 433) | 282 (65%) | 127 (29%) | 24 (6%) | 388 (90%) | 45 (10%) |
Ki67 expression | |||||
<10% (n = 168) | 127 (75%) | 35 (21%) | 7 (4%) | 162 (96%) | 7 (4%) |
10–20% (n = 576) | 379 (66%) | 179 (31%) | 18 (3%) | 524 (91%) | 52 (9%) |
21–30% (n = 611) | 337 (55%) | 227 (37%) | 47 (8%) | 508 (83%) | 103 (17%) |
>30% (n = 377) | 142 (38%) | 146 (39%) | 89 (24%) | 247 (66%) | 130 (34%) |
Histology | |||||
Lobular | 144 (67%) | 61 (29%) | 9 (4%) | NA | NA |
Patient age | |||||
<35 Years (n = 26) | 10 (38%) | 12 (46%) | 4 (15%) | 19 (73%) | 7 (27%) |
35–50 Years (n = 655) | 403 (62%) | 201 (31%) | 51 (8%) | 566 (86%) | 89 (14%) |
51–70 Years (n = 831) | 443 (53%) | 304 (37%) | 84 (10%) | 675 (81%) | 156 (19%) |
>70 Years (n = 226) | 131 (58%) | 71 (31%) | 24 (11%) | 184 (81%) | 42 (19%) |
Menopausal status | |||||
Pre (n = 623) | 378 (61%) | 196 (31%) | 49 (8%) | 535 (84%) | 88 (16%) |
Peri (n = 137) | 75 (55%) | 48 (35%) | 14 (10%) | 116 (85%) | 21 (15%) |
Post (n = 960) | 522 (54%) | 339 (35%) | 99 (10%) | 777 (81%) | 183 (19%) |
