Table 2 Frequency of genetic alterations affecting TERT gene in 60 metaplastic breast cancers according to their predominant histologic component.
From: TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer
Predominant histologic component | ||||||
---|---|---|---|---|---|---|
MBCs | SQUAMOUS | SPINDLE | OSSEOUS | CHONDROID | p valuea | |
(n = 60) | (n = 14) | (n = 16) | (n = 5) | (n = 25) | ||
TERT genetic alteration | 10 (17%) | 3 (21%) | 5 (31%) | 2 (40%) | 0 | 0.005 |
TERT wild-type | 50 (83%) | 11 (79%) | 11 (69%) | 3 (60%) | 25 (50%) |