Fig. 2

ER and PR pathway analysis, stratified by allelic status (a–d) and hormone status (e–h). a GO intracellular ER signature pathway. b GO positive regulatory ER pathway. c GO negative regulatory ER pathway. d GO response to progesterone pathway (only samples with available RNA-seq data were included in this analysis). e GO intracellular ER signature pathway. f GO positive regulatory ER pathway. g GO negative regulatory ER pathway. h GO response to progesterone pathway. Boxplots represent medians (centre line) and interquartile range, and whiskers represent the maximum and minimum values within 1.5 times the interquartile range from the edge of the box. Each data point represents an individual sample. P values: Comparison of each category vs non-carrier. ***p < 0.001; **p < 0.01; *p < 0.05; Mann–Whitney U test (bootstrap analysis was applied).