Fig. 5: Comparison of immune profiles of tumours (with integrated germline and somatic alterations) that arise from mutation carriers of PALB2, BRCA1 and BRCA2 and non-carriers.
From: Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses
a Cytolytic index (CYT), as measure of CD8+ T cell cytotoxicity. b ESTIMATE score, as measure of lymphocytic infiltration. c Distribution of TILs and PD-L1 expression. Only samples with IHC images for analysis were included in this analysis. d Representative images of H&E and IHC for CD3, CD4 and CD8 where image analysis was performed. Boxplots represent medians (centre line) and interquartile range, and whiskers represent the maximum and minimum values within 1.5 times the interquartile range from the edge of the box. Each data point represents an individual sample. P values: Comparison of each category vs non-carrier. **p < 0.01; *p < 0.05; Mann–Whitney U test (CD3, CD4 and CD8); Chi-square test (PD-L1 positive score).
