Table 3 Univariate and multivariate Cox regression analyses for DFS in Luminal B breast cancer patients.
From: The CINSARC signature predicts the clinical outcome in patients with Luminal B breast cancer
All patients | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
N | HR [95% CI] | p-value | N | HR [95% CI] | p-value | ||
Patients’ age | >50 vs. ≤50 | 1126 | 0.66 [0.52–0.84] | 5.73E−04 | 759 | 0.69 [0.47–1.03] | 0.070 |
Pathological tumor type | lobular vs. ductal | 895 | 1.86 [1.21–2.84] | 1.47E−02 | 759 | 2.17 [1.38–3.39] | 7.18E-04 |
other vs. ductal | 0.94 [0.60–1.47] | 759 | 1.19 [0.73–1.92] | 0.485 | |||
Pathological grade | 2 vs. 1 | 938 | 1.23 [0.75–2.00] | 0.077 | |||
3 vs. 1 | 1.51 [0.93–2.46] | ||||||
Pathological axillary lymph node status | positive vs. negative | 1221 | 1.69 [1.38–2.07] | 4.75E−07 | 759 | 2.55 [1.79–3.63] | 1.83E−07 |
Pathological tumor size | pT2 vs. pT1 | 1153 | 1.48 [1.17–1.88] | 2.24E−07 | 759 | 1.52 [1.10–2.10] | 1.14E−02 |
pT3 vs. pT1 | 2.96 [1.99–4.38] | 759 | 3.25 [1.89–5.58] | 2.09E−05 | |||
Adjuvant chemotherapy | yes vs. no | 1110 | 1.51 [1.13–2.01] | 5.41E−03 | 759 | 1.08 [0.72–1.64] | 0.702 |
Adjuvant hormone therapy | yes vs. no | 1104 | 0.74 [0.60–0.92] | 6.93E−03 | 759 | 0.69 [0.47–0.99] | 4.48E−02 |
CINSARC classes | High vs. Low-risk | 1438 | 1.43 [1.18–1.73] | 2.18E−04 | 759 | 1.46 [1.09–1.96] | 1.20E−02 |
Patients with adjuvant HT and without adjuvant CT | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
N | HR [95% CI] | p-value | N | HR [95% CI] | p-value | ||
Patients’ age | >50 vs. ≤50 | 517 | 0.99 [0.50–1.96] | 0.985 | |||
Pathological tumor type | lobular vs. ductal | 482 | 1.71 [0.94–3.12] | 0.195 | |||
other vs. ductal | 0.92 [0.49–1.71] | ||||||
Pathological grade | 2 vs. 1 | 407 | 0.84 [0.38–1.85] | 0.871 | |||
3 vs. 1 | 0.81 [0.37–1.78] | ||||||
Pathological axillary lymph node status | positive vs. negative | 535 | 2.88 [1.98–4.19] | 3.13E−08 | 494 | 2.9 [1.91–4.40] | 6.23E−07 |
Pathological tumor size | pT2 vs. pT1 | 513 | 1.87 [1.24–2.82] | 1.76E−06 | 494 | 1.76 [1.16–2.66] | 7.68E−03 |
pT3 vs. pT1 | 5.21 [2.76–9.83] | 494 | 4.71 [2.47–8.98] | 2.41E−06 | |||
CINSARC classes | High vs. Low-risk | 554 | 1.60 [1.11–2.30] | 1.11E−02 | 494 | 1.62 [1.11–2.37] | 1.16E−02 |
