Table 3 All metabolites that met q-value < 0.2 in at least one primary model analysis that adjusts for matching factors. M1 is the simple model^a (accounting for matching factors) and M2 is the adjusted model^b (adjusting for matching factors and breast cancer risk factors).

From: Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

Metabolite	Model	Logistic odds ratio	Logistic P-value	Lasso odds ratio	Lasso P-value	Elastic net odds ratio	Elastic net P-value	Random forest P-value
DMGV	M1	0.84	9.23E−05	0.87	4.00E−02	0.90	5.60E−02	<0.01
DMGV	M2	0.88	1.10E−02	0.89	6.80E−02	0.96	1.64E−01	<0.01
2-aminohippuric acid	M1	0.84	1.42E−04	0.93	2.24E−01	0.94	2.48E−01	0.02
2-aminohippuric acid	M2	0.85	7.72E−04	0.92	1.56E−01	0.96	9.60E−02	0.02
Piperine	M1	0.85	4.59E−04	0.80	0.00E+00	0.85	0.00E+00	<0.01
Piperine	M2	0.84	2.79E−04	0.78	0.00E+00	0.92	1.60E−02	<0.01
Kynurenic acid	M1	0.87	3.00E−03	0.87	2.80E−02	0.90	5.60E−02	0.1
Kynurenic acid	M2	0.86	2.92E−03	0.86	1.20E−02	0.96	8.80E−02	0.11
N2,N2-dimethyl-guanosine	M1	0.88	8.47E−03	1.00	1.00E+00	0.97	6.04E−01	<0.01
N2,N2-dimethyl-guanosine	M2	0.91	6.01E−02	1.00	5.04E−01	0.98	3.04E−01	0.05
Phenylacetyl-glutamine	M1	0.89	1.15E−02	0.88	2.80E−02	0.90	5.20E−02	0.13
Phenylacetyl-glutamine	M2	0.90	2.13E−02	0.89	2.40E−02	0.96	9.20E−02	0.19
C34:3 PC plasmalogen	M1	1.13	7.64E−03	1.24	2.80E−02	1.09	1.28E−01	0.01
C34:3 PC plasmalogen	M2	1.09	7.44E−02	1.29	1.60E−02	1.03	1.64E−01	<0.01
C20:1 LPC	M1	1.13	9.00E−03	1.08	2.44E−01	1.06	3.80E−01	0.17
C20:1 LPC	M2	1.10	5.18E−02	1.14	6.00E−02	1.02	2.76E−01	0.25
C40:7 PE plasmalogen	M1	1.14	3.23E−03	1.25	0.00E+00	1.11	6.80E−02	0.01
C40:7 PE plasmalogen	M2	1.11	3.01E−02	1.29	0.00E+00	1.03	1.28E−01	0.04
Asparagine	M1	1.14	6.10E−03	1.22	2.80E−02	1.13	3.20E−02	0.02
Asparagine	M2	1.10	5.41E−02	1.18	4.40E−02	1.04	1.20E−01	0.03
Creatine	M1	1.10	3.94E−02	1.27	0.00E+00	1.16	1.20E−02	0.06
Creatine	M2	1.13	1.51E−02	1.24	0.00E+00	1.05	5.60E−02	0.07

^aSimple model: adjusts for matching factors including menopausal status at blood draw, time of blood draw, date/season of blood draw, luteal day at blood draw, fasting status at blood draw, menopausal status at diagnosis and race
^bAdjusted model: in addition to matching factors, this model adjusts for BMI at age 18, weight change between age 18 and time of blood draw, age at menarche, parity and age at first birth, family history of breast cancer, personal history of benign breast disease, physical activity, alcohol consumption, exogenous hormone use, breast feeding history

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Table 3 All metabolites that met q-value < 0.2 in at least one primary model analysis that adjusts for matching factors. M1 is the simple model^a (accounting for matching factors) and M2 is the adjusted model^b (adjusting for matching factors and breast cancer risk factors).

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