Table 3 ORs and 95% CIs for the associations between breast cancer risk and APD and PMD, cross-classified with V, in NHS/NHSIIa.

From: Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study

 

V

 

PMD

Quartile 1 < −0.76

Quartile 2 −0.76–< −0.09

Quartile 3 −0.09–0.56

Quartile 4 > 0.56

p interaction

Quartile 1 < 16

Ref

1.28 (0.96, 1.69)

1.32 (0.86, 2.04)

1.40 (0.48, 4.07)

0.75

Quartile 2 16–<30

1.35 (1.00, 1.83)

1.71 (1.31, 2.22)

1.83 (1.38, 2.43)

1.67 (1.17, 2.38)

Quartile 3 30–<46

1.43 (0.89, 2.28)

2.01 (1.47, 2.73)

2.01 (1.53, 2.64)

2.73 (2.11, 3.52)

Quartile 4 ≥ 46

2.50 (1.51, 4.14)

2.94 (2.12, 4.09)

3.22 (2.45, 4.24)

3.57 (2.79, 4.58)

APD

    

p interaction

Quartile 1 < 14

Ref

1.50 (1.10, 3.04)

1.81 (0.88, 3.73)

2.81 (0.62, 12.7)

0.75

Quartile 2 14–<18

1.52 (1.12, 2.07)

1.56 (1.26, 1.93)

2.01 (1.54, 2.64)

2.10 (1.38, 3.21)

Quartile 3 18–<21

0.56 (0.13, 2.50)

1.52 (1.15, 2.02)

1.61 (1.27, 2.03)

2.19 (1.70, 2.80)

Quartile 4 ≥ 21

Not estimated

2.02 (1.25, 3.26)

2.09 (1.62, 2.69)

2.49 (2.02, 3.06)

  1. OR odds ratio, CI confidence interval, PMD percent mammographic density, APD automated percent density, V variation measure, NHS Nurses’ Health Study, NHSII Nurses’ Health Study II.
  2. aModels are adjusted for: Age (continuous), fasting status, time of blood draw, body mass index (kg/m2), menopausal status (premenopausal, postmenopausal, unknown), hormone therapy use (never, past, current, unknown), mammography read batch (batch 1, batch 2, batch 3).
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