Table 4 ORs and 95% CIs for the associations between breast cancer risk and APD and PMD with mutual adjustment, in NHS/NHSIIa.

From: Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study

PMD

Not adjusted for APD

Adjusted for APD

Quartile 1 < 16

Ref

Ref

Quartile 2 16–<30

1.47 (1.23, 1.75)

1.33 (1.11, 1.61)

Quartile 3 30–<46

1.97 (1.64, 2.37)

1.66 (1.35, 2.05)

Quartile 4 ≥ 46

2.90 (2.39, 3.52)

2.40 (1.91, 3.00)

p trend

<0.0001

<0.0001

Per 1 SD

1.52 (1.42, 1.63)

1.43 (1.33, 1.55)

APD

Not adjusted for PMD

Adjusted for PMD

Quartile 1 < 14

Ref

Ref

Quartile 2 14–<18

1.52 (1.28, 1.80)

1.32 (1.11, 1.57)

Quartile 3 18–<21

1.57 (1.31, 1.87)

1.15 (0.96, 1.40)

Quartile 4 ≥ 21

2.10 (1.75, 2.51)

1.40 (1.15, 1.70)

p trend

<0.0001

0.0048

Per 1 SD

1.33 (1.24, 1.41)

1.14 (1.06, 1.22)

  1. OR odds ratio, CI confidence interval, PMD percent mammographic density, APD automated percent density, V variation measure, NHS Nurses’ Health Study, NHSII Nurses’ Health Study II.
  2. aModels adjusted for: Age (continuous), fasting status, time of blood draw, body mass index (kg/m2), menopausal status (premenopausal, postmenopausal, unknown), hormone therapy use (never, past, current, unknown), mammography read batch (batch 1, batch 2, batch 3). PMD adjusted for continuous automated percent MD and vice versa.
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