Table 1 Clinicopathological characteristics of the study cohort.

From: The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

Number of patients

35

p value (Fisher’s exact test)

Age (mean)

52.8 years

 

Histologic grade

Diagnosis

Surgery

 

Grade 1

4

1

 

Grade 2

16

18

 

Grade 3

14

14

0.5

Missing or not available

1

2

 

ER status

   

ER+

21

18

 

ER−

14

15

0.8

Missing or not available

0

2

 

PR status

   

PR+

17

17

 

PR−

18

16

1

Missing or not available

0

2

 

KI67 at diagnosis

   

> or = 14%

28

30

 

<14%

7

3

0.3

Missing or not available

0

2

 

Clinical tumour stage at diagnosis

   

T0

0

2

 

T1

1

21

 

T2

31

10

 

T3

2

1

<0.001

Node

   

N0

24

19

 

N1

11

12

 

N2

0

4

0.1

Histology

   

IDC

30

27

 

ILC

2

2

 

other

3

4

0.9

Missing or not available

2

 

Treatment response

pCR

2

 

Good responders (CR or PR)

19 (5 CR, 14 PR)

 

Poor responders (PR or SD)

16 (12 SD, 4 PD)

 

Missing or not available

3

 

Residual cancer burden (RCB) after neoadjuvant treatment

RCB1 = 1, RCB2 = 18, RCB3 = 13 patients, NA = 3

Recurrence

6