Table 2 Gene ontology association with important biological pathways.
Visit | Effect in tested group (poor responders) | Pathway Database | Pathway | Genes | p value |
|---|---|---|---|---|---|
V1 | Increased | GO:0045766 | Positive regulation of angiogenesis | PTGS2, VEGFA, AKT3, ADM, ANGPTL4 and CXCL8 | 0.00697 |
KEGG:04066 | HIF-1 signalling pathway | VEGFA, AKT3, ERBB2 and EGFR | 0.0276 | ||
GO:0050678 | Regulation of epithelial cell proliferation | STRAP, VEGFA, AKT3, MYC, ERBB2, EGFR and NFIB | 0.0217 | ||
GO:1901342 | Regulation of vasculature development | PTGS2, VEGFA, AKT3, ERBB2, ADM, ANGPTL4 and CXCL8 | 0.0462 | ||
V3 | Decreased | GO:0046649 | Lymphocyte activation | ERCC1, IGF1, IGBP1, CD86, IGFBP2, CDKN1A, VAV3, IL6ST, PIK3R1, ZEB1, TGFBR2, AXL, PTGER4 and KIF13B | 0.0000413 |
GO:0042110 | T cell activation | IGF1, CD86, IGFBP2, IL6ST, PIK3R1, ZEB1, TGFBR2, PTGER4 and KIF13B | 0.0227 | ||
GO:0043069 | Negative regulation of programmed cell death | IGF1, IGBP1, NR4A3, TWIST1, CDKN1A, IL6ST, KLF4, SLC40A1, CYR61, PIK3R1, BTG2, AXL and TWIST2 | 0.00716 | ||
GO:0043066 | Negative regulation of the apoptotic process | IGF1, IGBP1, NR4A3, TWIST1, CDKN1A, IL6ST, KLF4, SLC40A1, CYR61, PIK3R1, BTG2, AXL and TWIST2 | 0.00595 | ||
Increased | GO:0012501 | Programmed cell death | YBX3, GAL, MCM2, BIRC5, AARS, ITGA6, MYBL2, NDRG1, VEGFA, SNAI1, KRT17, TOP2A, CDK4, MYC, BRCA2, TP53BP2, CDCA7, HSPD1, ADM, CHEK1, MAD2L1, ANGPTL4, DDIT4, BUB1, CDK1, KRT19, KRT5, KRT14, S100A14 and PGAM5 | 0.00385 | |
GO:0008283 | Cell proliferation | TACC3, STRAP, LAMC2, CDH3, GAL, GRHL2, BIRC5, CDC6, CDKN3, NDRG1, EZH2, FOXM1, BYSL, VEGFA, TTK, CDC20, CENPF, CKS2, DLGAP5, CCNB1, CDK4, MYC, BRCA2, KIF2C, CDCA7, HSPD1, CCNA2, MKI67, ADM, CHEK1, BTG3, CDC25C, FZD6, DDIT4, CXCL8, BUB1, CDK1, CTPS1, FANCA, PRC1 and BOP1 | 0.00000000266 |
