Fig. 3: Genomic and transcriptomic analyses of tissues from metastatic TNBC to detect associations with durable responses after nivolumab with cabozantinib.

a Whole-exome sequencing breast cancer gene alterations in baseline, on-treatment, and post-treatment tissue and blood biopsies from six patients showed no clear association with response: each column represents a tumor or blood biopsy with samples grouped by patient ordered from longest to shortest progression-free survival. b Hallmark geneset enrichment analyses of gene expression data revealed immune geneset enrichment in patient with durable response that increased on-treatment, as shown in first two columns. Muts/Mb mutations per megabase, Nonsyn nonsynonymous, PD progressive disease, PR partial response, Pt patient, SD stable disease, Tx treatment.