Table 1 Baseline characteristics.

From: Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study

Characteristic

Number of patients (%)

Age, years

 

 Median (range)

58 (41–71)

Sex

 

 Female

18 (100)

Race

 

 White

15 (83)

 Black

1 (6)

 Other

2 (11)

ECOG PS at baseline

 

 0

18 (100)

Sites of disease

 

 Lung pleural

6 (33)

 Liver

7 (39)

 Bone

8 (44)

 Breast/chest wall

7 (39)

 Lymph node

11 (61)

 Soft tissue

3 (17)

Adjuvant or neoadjuvant treatment

 Adjuvant or neoadjuvant hormonal therapy

1 (6)

 Adjuvant or or neoadjuvant anthracycline

12 (67)

 Adjuvant or neoadjuvant taxane

12 (67)

Lines of chemotherapy for metastasis or recurrence

 

 Median (range)

1 (0–3)

 0

5 (28)

 1

6 (33)

 2

5 (28)

 3

2 (11)

Prior metastatic chemotherapy

 

 Anthracycline

4 (22)

 Taxane

5 (28)

 Platinum

11 (61)

 Capecitabine

2 (11)

 Eribulin

2 (11)

 Other chemotherapy

6 (33)

ER, PR, and HER2 status at study entry

 

 ER and/or PR-positive (≤10%), HER2-negative

2 (11)

 ER and PR negative, HER2-negative

16 (89)

PD-L1-positive cellsa

1 (7)

TILs in metastatic samplesb

3 (27)

  1. ECOG PS Eastern Cooperative Oncology Group Performance Status, ER estrogen receptor, HER2 human epidermal growth factor receptor 2, PR progesterone receptor, TIL tumor-infiltrating lymphocytes.
  2. aPD-L1 was successfully evaluated in 15 patients (8 primary and 7 metastatic samples).
  3. bTILs analysis was available in metastatic samples from 11 patients.