Table 3 Univariate and multivariate Cox regression analyses of germinal center numbers in cancer-free LNs for iDFS, dDFS, and OS of HR-negative, their TILs subgroups, all TNBC and low TILs TNBC.

From: Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication

 

Covariate P

Model P

HR

CI

(A) All HR-negative cases

iDFS

 All cases (n = 161)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.33

0.19–0.59

  Multivariatea - Total GCs number (≤2 v > 2)

0.110

<0.001

0.58

0.30–1.12

 <20% sTILs (n = 86)

    

  Univariate - Total GCs number (≤2 v > 2)

/

0.002

0.36

0.19–0.69

  Multivariateb - Total GCs number (≤2 v > 2)

0.023

0.004

0.41

0.19–0.89

 ≥20% sTILs (n = 75)

    

  Univariate - Total GCs number (≤2 v > 2)

/

0.804

1.29

0.16–10.16

  Multivariateb - Total GCs number (≤2 v > 2)

0.949

0.034

0.93

0.11–7.93

dDFS

 All cases (n = 161)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.26

0.14–0.48

  Multivariatea - Total GCs number (≤2 v > 2)

0.033

<0.001

0.47

0.23–0.94

 <20% sTILs (n = 86)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.28

0.14–0.56

  Multivariateb - Total GCs number (≤2 v > 2)

0.009

<0.001

0.34

0.17–0.77

 ≥20% sTILs (n = 75)

  Univariate - Total GCs number (≤2 v > 2)

/

0.986

1.02

0.13–8.29

  Multivariateb - Total GCs number (≤2 v > 2)

0.665

0.031

0.61

0.07–5.64

OS

 All cases (n = 161)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.28

0.14–0.55

  Multivariatea - Total GCs number (≤2 v > 2)

0.351

<0.001

0.69

0.32–1.50

 <20% sTILs (n = 86)

  Univariate - Total GCs number (≤2 v > 2)

/

0.006

0.36

0.17–0.75

  Multivariateb - Total GCs number (≤2 v > 2)

0.106

0.001

0.48

0.20–1.17

 ≥20% sTILs (n = 75)

  Univariate - Total GCs number (≤2 v > 2)

/

0.652

0.59

0.07–5.25

  Multivariateb - Total GCs number (≤2 v > 2)

-c

-c

-c

-c

(B) Triple-negative breast cancers

iDFS

 All cases (n = 99)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.25

0.12–0.52

  Multivariatea - Total GCs number (≤2 v > 2)

0.017

<0.001

0.37

0.16–0.84

 <20% sTILs (n = 52)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.25

0.11–0.57

  Multivariateb - Total GCs number (≤2 v > 2)

0.003

0.016

0.26

0.10–0.64

dDFS

 All cases (n = 99)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.20

0.09–0.44

  Multivariatea - Total GCs number (≤2 v > 2)

0.004

<0.001

0.29

0.13–0.67

 <20% sTILs (n = 52)

  Univariate - Total GCs number (≤2 v > 2)

/

<0.001

0.21

0.09–0.49

  Multivariateb - Total GCs number (≤2 v > 2)

0.001

0.004

0.21

0.08–0.55

OS

 All cases (n = 99)

  Univariate - Total GCs number (≤2 v > 2)

/

0.004

0.24

0.10–0.60

  Multivariatea - Total GCs number (≤2 v > 2)

0.119

<0.001

0.46

0.17–1.22

 <20% sTILs (n = 52)

  Univariate - Total GCs number (≤2 v > 2)

/

0.013

0.29

0.11–0.76

  Multivariateb - Total GCs number (≤2 v > 2)

0.036

0.005

0.32

0.11–0.93

  1. aAdjusted for Age, pTstage, pNstage, LVI, sTILs & TLS
  2. bAdjusted for Age, pTstage, pNstage, LVI & TLS
  3. cGroup size too small/too few events.
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