Table 3 Prosigna-trained results stratified by other test results, trinary classification.

From: Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study

Prosigna-trained first

 

Prosigna-trained low risk

Prosigna-trained intermediate risk

Prosigna-trained high risk

 

HR (95% CI)

DMFS (95% CI)

P* (N)

HR (95% CI)

DMFS (95% CI)

P (N)

HR (95% CI)

DMFS (95% CI)

P (N)

All cases

REF

92.1

(89.8–94.0)

<0.001

(826)

1.97

(1.44–2.69)

84.9

(82.3–87.1)

<0.001

(1155)

4.24

(3.18–5.66)

71.4

(68.6–74.1)

<0.001

(1303)

N−Ch−

REF

96.7

(92.0–98.7)

<0.001

(220)

3.06

(1.16–8.08)

91.0

(86.4–94.1)

0.024

(321)

7.76

(3.13–19.2)

80.5

(75.7–84.3)

<0.001

(429)

N+Ch−

REF

90.1

(85.8–93.2)

<0.001

(318)

1.35

(0.85–2.15)

86.2

(82.1–89.4)

0.204

(476)

4.43

(2.93–6.69)

63.9

(58.6–68.7)

<0.001

(453)

Ch+

REF

90.9

(86.3–94.0)

<0.001

(287)

2.64

(1.63–4.27)

77.8

(72.5–82.2)

<0.001

(356)

3.74

(2.37–5.92)

70.4

(65.2–74.9)

<0.001

(417)

 

Oncotype-trained Low

Oncotype-trained Int

Oncotype-trained high

Oncotype-trained low

Oncotype-trained Int

Oncotype-trained high

Oncotype-trained low

Oncotype-trained Int

Oncotype-trained high

HR

DMFS

P*

HR

DMFS

P

HR

DMFS

P

HR

DMFS

P*

HR

DMFS

P

HR

DMFS

P

HR

DMFS

P*

HR

DMFS

P

HR

DMFS

P

All cases

REF

92.2

(89.5–94.2)

0.737

(643)

1.07

(0.56–2.03)

91.5

(85.2–95.2)

0.835

(174)

NA

100

NA

(9)

REF

88.5

(85.3–91.0)

<0.001

(685)

1.86

(1.31-2.66)

81.4

(76.5-85.4)

0.001

(381)

3.08

(1.89-5.01)

72.6

(61.0-81.3)

<0.001

(89)

REF

75.4

(68.3–81.1)

<0.001

(279)

1.27

(0.92–1.75)

73.3

(69.2–77.0)

0.148

(618)

1.78

(1.28–2.47)

65.7

(60.4–70.5)

0.001

(406)

N−Ch−

REF

97.1

(92.5–98.9)

0.955

(174)

1.03

(0.12–9.26)

94.1

(65.0–99.1)

0.976

(43)

NA

100

NA

(3)

REF

92.4

(86.3-95.8)

0.395

(189)

1.69

(0.72-3.97)

87.5

(77.3-93.4)

0.232

(106)

0.69

(0.09-5.34)

94.7

(68.1-99.2)

0.721

(26)

REF

83.8

(70.1-91.6)

0.012

(95)

1.26

(0.61-2.59)

83.7

(77.1-91.6)

0.535

(200)

2.35

(1.15-4.78)

72.8

(63.4-80.2)

0.019

(134)

N+Ch−

REF

89.3

(84.4–92.7)

0.701

(263)

0.62

(0.19–2.07)

94.3

(83.4–98.1)

0.441

(54)

NA

100

NA

(1)

REF

89.1

(84.1-92.5)

0.008

(309)

1.93

(1.09-3.43)

81.8

(73.1-87.9)

0.025

(142)

3.21

(1.32-7.80)

74.5

(51.7–87.7)

0.010

(25)

REF

70.3

(58.1–79.6)

<0.001

(111)

1.29

(0.80–2.09)

69.0

(61.4–75.4)

0.291

(207)

2.27

(1.41–3.65)

51.1

(41.5–59.8)

0.001

(135)

Ch+

REF

91.9

(86.5–95.2)

0.552

(205)

1.51

(0.63–3.60)

87.9

(76.9–93.9)

0.353

(77)

NA

100

NA

(5)

REF

83.4

(76.0-88.7)

<0.001

(185)

1.72

(1.01-2.94)

76.2

(67.4-83.0)

0.046

(133)

3.47

(1.83-6.58)

56.4

(37.0–71.9)

<0.001

(38)

REF

71.7

(57.0–82.1)

0.644

(73)

1.24

(0.71–2.15)

67.4

(59.7–74.0)

0.445

(208)

1.06

(0.58–1.92)

73.8

(65.1–80.7)

0.854

(136)

 

Mammaprint-trained low

 

Mammaprint trained high

Mammaprint-trained low

 

Mammaprint-trained high

Mammaprint-trained low

 

Mammaprint-trained high

HR

DMFS

P*

   

HR

DMFS

P

HR

DMFS

P*

   

HR

DMFS

P

HR

DMFS

P*

   

HR

DMFS

P

All cases

REF

92.2

(89.8–94.0)

0.753

(814)

   

1.37

(0.19–9.92)

90.0

(47.3–98.5)

0.754

(12)

REF

86.1

(83.3–88.5)

0.005

(944)

   

1.69

(1.16–2.44)

79.4

(72.6–84.7)

0.006

(211)

REF

78.1

(73.0–82.3)

<0.001

(422)

   

1.64

(1.26–2.12)

68.4

(64.9–71.7)

<0.001

(881)

N−Ch−

REF

96.6

(91.8–98.6)

0.763

(217)

   

NA

100

NA

(3)

REF

93.1

(88.1–96.0)

0.031

(249)

   

2.47

(1.06–5.79)

83.8

(70.2–91.5)

0.037

(72)

REF

89.6

(80.6–94.5)

0.002

(133)

   

2.78

(1.43–5.44)

76.5

(70.6–81.4)

0.003

(296)

N+Ch−

REF

90.0

(85.7–93.1)

0.601

(315)

   

NA

100

NA

(3)

REF

86.6

(82.2–90.0)

0.371

(415)

   

1.38

(0.68–2.84)

83.6

(70.7–91.1)

0.373

(61)

REF

75.7

(66.8–82.5)

<0.001

(166)

   

2.09

(1.41–3.10)

57.4

(50.8–63.5)

<0.001

(287)

Ch+

REF

91.1

(86.5–94.2)

0.280

(281)

   

2.88

(0.39–21.4)

75.0

(12.8–96.1)

0.302

(6)

REF

79.3

(73.3–84.2)

0.066

(278)

   

1.62

(0.96-2.73)

72.7

(60.8-81.5)

0.069

(78)

REF

69.0

(58.8-77.2)

0.948

(122)

   

0.99

(0.65-1.49)

70.9

(64.7-76.2)

0.948

(295)

  1. HR = Hazard ratio. 95%CI = 95% confidence interval. P* = p value of log-rank test to compare survival distributions. REF = reference group. P = p value of Wald test for comparison versus reference (low risk) group. DMFS = distant metastasis free survival at 10 years (see text). (N) = number of cases in subgroups. All cases = all ER+ve/HER2-ve cases. N−Ch− = Node negative cases treated without chemotherapy. N+Ch− = Node positive cases treated without chemotherapy. Ch+= cases treated with chemotherapy (node negative and node positive combined). Int = intermediate.
Back to article page