Fig. 2: Analysis of genomic deletions in RAD51B-associated cancers. | npj Breast Cancer

Fig. 2: Analysis of genomic deletions in RAD51B-associated cancers.

From: Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

Fig. 2

A Number of deletions in biallelic RAD51B-associated cancers, monoallelic RAD51B-associated cancers, biallelic BRCA1-associated cancers and biallelic BRCA2-associated cancers. Note one mon-allelic RAD51B was removed from the plot due to a large number of indels (142) driven by microsatellite instability. B Median deletion length in biallelic RAD51B-associated cancers, monoallelic RAD51B-associated cancers, biallelic BRCA1-associated cancers and biallelic BRCA2-associated cancers. C Deletion microhomology scores in biallelic RAD51B-associated cancers, monoallelic RAD51B-associated cancers, biallelic BRCA1-associated cancers and biallelic BRCA2-associated cancers. A deletion was classified as having microhomology when deletion length was ≥4 bases with homology ≥3 bases. Microhomology scores are calculated by dividing the total number of deletions with microhomology by the total number of deletions.

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