Table 1 Germline RAD51B pathogenic variants in MSK vs. gnomAD cohorts.

From: Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

 

MSK cohort

gnomAD cohort

Comparative Statistics

 

Individuals with RAD51B truncating variant (n)

Total individuals (n)

Carrier frequency (%)

Individuals with RAD51B truncating variant (n)

Total individuals (n)

Carrier frequency (%)

OR

95%CI

P value

Pan-cancer

13

18,087

0.07%

136

138,632

0.10%

0.73

0.4–1.3

0.28

Breast and ovarian cancer

9

3422

0.26%

136

138,632

0.10%

2.69

1.4–5.3

0.004

  1. MSK Memorial Sloan Kettering, gnomAD The Genome Aggregation Database, OR odds ratio, CI confidence interval, NP not performed.
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