Fig. 4: Five-gene metabolic signature is enriched in TNBC patients when compared to ER+ breast cancer patients.
From: Oncogene-mediated metabolic gene signature predicts breast cancer outcome
a–d Heatmap displaying mRNA levels of Trop2 associated 5-gene metabolic signature (TALDO1, GPI, SHMT2, LDHA, and ADK) and known oncogenes (TAGLN2, NOLC1, HSP90AB1, HDGF, MCM5, and NCL) in breast cancer patient samples (upper panel). The red color indicates a higher z-score whereas blue represents a lower z-score. Individual gene expression levels (TALDO1, GPI, SHMT2, LDHA, and ADK) are presented as dot plots (lower panel). The mRNA levels of the identified 5-gene metabolic signature in METABRIC 57 and TCGA (Firehose Legacy) clinical datasets are obtained from cBioPortal for Cancer Genomics (https://www.cbioportal.org/)58,59. The mRNA levels of the identified 5-gene metabolic signature in E-MTAB-365 60 and GSE21653 61 clinical datasets are shown. Error bars represent standard deviation. Adjusted P value was calculated based on Bonferroni testing in Prism software. **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns not significant.
