Fig. 4: MRN and genome-wide alterations. | npj Breast Cancer

Fig. 4: MRN and genome-wide alterations.

From: Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers

Fig. 4

Differentially expressed genes (DEGs) were identified using RNAseq data from the TCGA-BRCA cohort dichotomized on the basis of low (quartile 1) versus high (quartile 4) expression of MRE11 (a), RAD50 (b) and NBN/NBS1 (c). We next identified DEGs that were low (77 genes) or higher (545 genes) in patients with lower expression of MRN components (d–f) and identified enriched KEGG pathways (d, e). Pathways related to mitochondrial dysfunction were associated with reduced MRN expression (f).

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