Fig. 5: Treatment activity based on Cycle2 Day 1 (C2D1) gene expression.
a Genes found differentially expressed in C2D1 samples between pCRB and no-pCRB in SAM analysis. Colored dots mark the genes with a false discovery rate (FDR) = 0, in red upregulate and in green downregulated. b Percentage of tumor cellularity at C2D1 according with pathologic complete response (pCR) or residual disease (non-pCR) at surgery and Normal-like subtype and non-normal-like subtype at C2D1. p-value was obtained after performing ANOVA test. c Variation of PAM50-based, claudin-low and hypoxia signatures (Baseline vs. C2D1). p-value was obtained after performing a paired t-test. Red lines mark the 9 patients, which achieve a pCRB at surgery and with paired samples in both timepoints (Baseline vs. C2D1). Error bars correspond to standard error of the mean.
