Fig. 1: Transcriptome profiles of 32 women with normal BMI. | npj Breast Cancer

Fig. 1: Transcriptome profiles of 32 women with normal BMI.

From: Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women

Fig. 1

a Heatmap demonstrating 226 upregulated and 137 downregulated differentially expressed genes (DEGs) from non-tumorous breast tissue of women with trunk fat high vs. trunk fat low. b Volcano plot illustrating the abundance of DEGs in (1) Trunk fat high vs. Trunk fat low and (2) BMI high vs. BMI low. Two vertical dashed lines correspond to −0.6 and 0.6, which are the Log2fold-change cutoffs for the DEGs. The horizontal dashed line corresponds to P adjusted value of 0.05, which is another cutoff for the DEG. c Biological pathway changes associated with increased trunk fat percent in normal BMI women. Gene ratio indicates the ratio of genes that are included within each pathway. q value is a p value that is adjusted for the false discovery rate. q < 0.05 is considered significant.

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