Fig. 1: PIK3CA gain and PIK3CA mRNA or mutational status. | npj Breast Cancer

Fig. 1: PIK3CA gain and PIK3CA mRNA or mutational status.

From: PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer

Fig. 1

Distribution of PIK3CA mRNA according to PIK3CA categories (a, b); PIK3CA gain according to mutational status (c); mutation exons (d), hotspots (e) and double mutations (f) according to PIK3CA gain status. Analyses were performed in HR + /HER2− BC within METABRIC using Mann–Whitney–Wilcoxon in a, b and Two-proportion z-test in c–f. Levels of PIK3CA log2ratio in primary and metastatic HR + /HER2− BC within MSK-2018 (g). Mann–Whitney–Wilcoxon test was performed. For box plots, lower and upper bars correspond to the minimum and maximum non-outlier values of the data distribution. Outliers are defined as values outside of the range (Q1 − 1.5×(Q3 − Q1), Q3 + 1.5×(Q3 − Q1)), where Q1 and Q3 are the first and third quartile, respectively.

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