Fig. 4: PIK3CA categories and response to alpelisib. | npj Breast Cancer

Fig. 4: PIK3CA categories and response to alpelisib.

From: PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer

Fig. 4

Box-plots of alpelisib IC50 data in BC cell lines (a) and change in tumor volume in BC PDX treated with alpelisib (b) according to the PIK3CA categories. Bar-plots of month on treatment for alpelisib-treated patients within ALP-201926,27 according to the PIK3CA categories (c). Bar-plots of weeks on study for alpelisib-treated patients within ALP-202025 according to the PIK3CA categories (d); Mann–Whitney–Wilcoxon tests were performed in a and b. For box plots, lower and upper bars correspond to the minimum and maximum non-outlier values of the data distribution. Outliers are defined as values outside of the range (Q1 − 1.5×(Q3 − Q1), Q3 + 1.5×(Q3 − Q1)), where Q1 and Q3 are the first and third quartile, respectively.

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