Table 1 PIK3CA categories and clinico-pathological characteristics in ER + /HER2− BC within METABRIC.
wt/neutral | wt/gain | mut/neutral | mut/gain | P value | ||
|---|---|---|---|---|---|---|
Age at diagnosis | <50 years | 116 (17%) | 9 (11%) | 85 (16%) | 18 (16%) | 0.61 |
>= 50 years | 549 (83%) | 70 (89%) | 433 (84%) | 97 (84%) | ||
Tumor grade | 1 | 53 (8%) | 2 (3%) | 96 (19%) | 9 (8%) | 5e-04 |
2 | 324 (49%) | 28 (35%) | 264 (51%) | 47 (41%) | ||
3 | 251 (38%) | 44 (56%) | 136 (26%) | 57 (50%) | ||
NA | 37 (6%) | 5 (6%) | 22 (4%) | 2 (2%) | ||
Tumor size (mm) | <= 20 | 294 (44%) | 32 (41%) | 254 (49%) | 38 (33%) | 0.035 |
>20 | 364 (55%) | 47 (59%) | 257 (50%) | 77 (67%) | ||
NA | 7 (1%) | 0 (0%) | 7 (1%) | 0 (0%) | ||
Nodal status | 0 | 342 (51%) | 32 (41%) | 299 (58%) | 64 (56%) | 5e−04 |
>= 1 | 290 (44%) | 38 (48%) | 219 (42%) | 51 (44%) | ||
NA | 33 (5%) | 9 (11%) | 0 (0%) | 0 (0%) | ||
Histological subtype | Ductal/NST | 476 (72%) | 64 (81%) | 352 (68%) | 92 (80%) | 0.007 |
Lobular | 61 (9%) | 4 (5%) | 45 (9%) | 11 (10%) | ||
Mixed | 80 (12%) | 8 (10%) | 92 (18%) | 10 (9%) | ||
Other | 31 (5%) | 2 (3%) | 27 (5%) | 1 (1%) | ||
NA | 17 (3%) | 1 (1%) | 2 (0%) | 1 (1%) | ||
Molecular subtype | LumA | 275 (41%) | 27 (34%) | 310 (60%) | 51 (44%) | 5e-04 |
LumB | 245 (37%) | 31 (39%) | 109 (21%) | 34 (30%) | ||
Other | 143 (22%) | 21 (27%) | 96 (19%) | 30 (26%) | ||
NA | 2 (0%) | 0 (0%) | 3 (1%) | 0 (0%) | ||
Integrative Clusters | 1 | 75 (11%) | 15 (19%) | 12 (2%) | 8 (7%) | 5e−04 |
2 | 33 (5%) | 2 (3%) | 20 (4%) | 8 (7%) | ||
3 | 95 (14%) | 8 (10%) | 155 (30%) | 20 (17%) | ||
4ER− | 8 (1%) | 2 (3%) | 4 (1%) | 1 (1%) | ||
4ER + | 118 (18%) | 6 (8%) | 79 (15%) | 16 (14%) | ||
5 | 1 (0%) | 0 (0%) | 1 (0%) | 4 (3%) | ||
6 | 58 (9%) | 4 (5%) | 9 (2%) | 6 (5%) | ||
7 | 85 (13%) | 6 (8%) | 76 (15%) | 10 (9%) | ||
8 | 121 (18%) | 13 (16%) | 131 (25%) | 24 (21%) | ||
9 | 57 (9%) | 15 (19%) | 30 (6%) | 12 (10%) | ||
10 | 14 (2%) | 8 (10%) | 1 (0%) | 6 (5%) |
