Fig. 3: Proportion of participants who experienced worsening of patient-reported outcome scores meeting or exceeding the minimal important difference at 3, 6, and 12 months.

Line graphs display percentage of participants with worsening of PRO scores compared to baseline at 3, 6, and 12 months after enrollment. Worsening of PRO scores is categorized as at least the MID but less than twice the MID, at least twice the MID but less than three times the MID and at least three times the MID for each measure. Only participants with baseline values and at least one follow-up measure are included. The percentage of participants whose PRO scores worsened by less than the MID (i.e. who experienced improvement, no change or worsening less than the MID) are not displayed. The MID was considered to be 4 points for the physical function, depression, anxiety, sleep disturbance, fatigue, and pain interference measures; 8 points for the sexual problems measure; and 5 points for the endocrine symptoms measure. MID minimal important difference, 1 MID at least the MID but less than twice the MID, 2 MID twice the MID but less than three times the MID, 3+ MID at least three times the MID, PRO patient-reported outcomes.