Table 1 Characteristics of study population according to type of endocrine therapy initiated at study enrollment.

From: Association of treatment-emergent symptoms identified by patient-reported outcomes with adjuvant endocrine therapy discontinuation

Characteristic

Overall Study Population

N = 321

Tamoxifen

N = 140

Aromatase Inhibitor

N = 181

Median (Q1-Q3) age in years

63 (56–71)

54 (49–59)

69 (64–74)

Post-menopausal – N (%)

210 (65.4)

34 (24.3)

176 (97.2)

Ovarian Function Suppression – N (%)

17 (5.3)

16 (11.4)

1 (0.6)

Switching Endocrine Therapya – N (%)

6 (1.9)

0 (0)

6 (3.3)

Race – N (%)

White

268 (83.5)

112 (80)

156 (86.2)

Black

33 (10.3)

16 (11.4)

17 (9.4)

Other

20 (6.2)

12 (8.6)

8 (4.4)

Neighborhood Poverty Rateb – N (%)

0–15%

274 (85.9)

116 (82.9)

158 (88.3)

>15%

45 (14.1)

24 (17.1)

21 (11.7)

Median number of concomitant medications at enrollment (range)

4 (0–29)

3 (0–29)

5 (0–22)

Stage – N (%)

0

28 (8.7)

18 (12.9)

10 (5.5)

I

191 (59.5)

80 (57.1)

111 (61.3)

II

79 (24.6)

39 (27.9)

40 (22.1)

III

23 (7.2)

3 (2.1)

20 (11)

ER-positive – N (%)c

320 (100)

139 (100)

181 (100)

PR-positive – N (%)c

282 (88.7)

128 (93.4)

154 (85.1)

HER2-positive – N (%)

26 (8.9)

10 (8.2)

16 (9.4)

Mastectomy – N (%)

143 (44.5)

76 (54.3)

67 (37)

Radiation – N (%)

215 (67)

85 (60.7)

130 (71.8)

Chemotherapy – N (%)

90 (28.2)

43 (30.9)

47 (26.1)

Median duration of follow-up in months (range)d

56.1 (6.9–87.7)

57.9 (9.1–87.7)

54.4 (6.9–87.3)

  1. Q1-Q3 interquartile range, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, SD standard deviation.
  2. a Participants were eligible to enroll at the time they first initiated adjuvant endocrine therapy or at the time of switching from one type of adjuvant endocrine therapy to another.
  3. b Neighborhood poverty rate is the percentage of persons living in a zip code with a family income below the federal poverty line based on United States census data. Neighborhood poverty rate was missing for two participants.
  4. c ER status was missing for one participant. PR status was missing for 3 participants.
  5. d Follow-up was calculated as the time from study entry to last clinic visit or last PRO survey completion, whichever came last.