Table 3 Change in symptoms compared to baseline at each time point through 12 months.
Symptom Domain | 3 months N (%) | 6 months N (%) | 12 months N (%) |
|---|---|---|---|
Physical Functiona | |||
No change or improvement | 189 (58.9) | 184 (57.3) | 150 (46.7) |
Worsening by less than the MID | 44 (13.7) | 28 (8.7) | 22 (6.9) |
Worsening by at least the MID but less than twice the MID | 28 (8.7) | 26 (8.1) | 19 (5.9) |
Worsening by at least twice the MID but less than three times the MID | 13 (4) | 9 (2.8) | 16 (5) |
Worsening by at least three times the MID | 8 (2.5) | 6 (1.9) | 7 (2.2) |
PRO not completed | 38 (11.8) | 67 (20.9) | 106 (33) |
Endocrine Symptomsb | |||
No change or improvement | 123 (38.3) | 106 (33) | 79 (24.6) |
Worsening by less than the MID | 74 (23.1) | 74 (23.1) | 57 (17.8) |
Worsening by at least the MID but less than twice the MID | 48 (15) | 40 (12.5) | 42 (13.1) |
Worsening by at least twice the MID but less than three times the MID | 22 (6.9) | 17 (5.3) | 19 (5.9) |
Worsening by at least three times the MID | 14 (4.4) | 15 (4.7) | 17 (5.3) |
PRO not completed | 39 (12.1) | 68 (21.2) | 106 (33) |
Sexual Problemsc | |||
No change or improvement | 201 (62.6) | 187 (58.3) | 114 (44.9) |
Worsening by less than the MID | 1 (0.3) | 0 (0) | 0 (0) |
Worsening by at least the MID but less than twice the MID | 18 (5.6) | 15 (4.7) | 19 (5.9) |
Worsening by at least twice the MID but less than three times the MID | 19 (5.9) | 15 (4.7) | 14 (4.4) |
Worsening by at least three times the MID | 38 (11.8) | 31 (9.7) | 33 (10.3) |
PRO not completed | 43 (13.4) | 72 (22.4) | 110 (34.3) |
Depressiona | |||
No change or improvement | 192 (59.8) | 175 (54.5) | 139 (43.3) |
Worsening by less than the MID | 31 (9.7) | 17 (5.3) | 22 (6.9) |
Worsening by at least the MID but less than twice the MID | 37 (11.5) | 28 (8.7) | 24 (7.5) |
Worsening by at least twice the MID but less than three times the MID | 12 (3.7) | 20 (6.2) | 15 (4.7) |
Worsening by at least three times the MID | 8 (2.5) | 10 (3.1) | 12 (3.7) |
PRO not completed | 40 (12.5) | 70 (21.8) | 108 (33.6) |
Anxietya | |||
No change or improvement | 180 (56.1) | 170 (53) | 136 (42.4) |
Worsening by less than the MID | 39 (12.1) | 34 (10.6) | 31 (9.7) |
Worsening by at least the MID but less than twice the MID | 29 (9) | 19 (5.9) | 23 (7.2) |
Worsening by at least twice the MID but less than three times the MID | 22 (6.9) | 16 (5) | 9 (2.8) |
Worsening by at least three times the MID | 11 (3.4) | 14 (4.4) | 15 (4.7) |
PRO not completed | 39 (12.1) | 67 (20.9) | 106 (33) |
Sleep Disturbancea | |||
No change or improvement | 146 (45.5) | 139 (43.3) | 120 (37.4) |
Worsening by less than the MID | 49 (15.3) | 40 (12.5) | 34 (10.6) |
Worsening by at least the MID but less than twice the MID | 50 (15.6) | 40 (12.5) | 27 (8.4) |
Worsening by at least twice the MID but less than three times the MID | 17 (5.3) | 18 (5.6) | 18 (5.6) |
Worsening by at least three times the MID | 20 (6.2) | 16 (5) | 16 (5) |
PRO not completed | 38 (11.8) | 67 (20.9) | 105 (32.7) |
Fatiguea | |||
No change or improvement | 158 (49.2) | 130 (40.5) | 116 (36.1) |
Worsening by less than the MID | 58 (18.1) | 53 (16.5) | 40 (12.5) |
Worsening by at least the MID but less than twice the MID | 33 (10.3) | 44 (13.7) | 38 (11.8) |
Worsening by at least twice the MID but less than three times the MID | 18 (5.6) | 14 (4.4) | 11 (3.4) |
Worsening by at least three times the MID | 14 (4.4) | 11 (3.4) | 10 (3.1) |
PRO not completed | 39 (12.1) | 68 (21.2) | 105 (32.7) |
Pain Interferencea | |||
No change or improvement | 209 (65.1) | 193 (60.1) | 153 (47.7) |
Worsening by less than the MID | 22 (6.9) | 17 (5.3) | 16 (5) |
Worsening by at least the MID but less than twice the MID | 23 (7.2) | 17 (5.3) | 26 (8.1) |
Worsening by at least twice the MID but less than three times the MID | 11 (3.4) | 11 (3.4) | 9 (2.8) |
Worsening by at least three times the MID | 16 (5) | 14 (4.4) | 10 (3.1) |
PRO not completed | 39 (12.1) | 68 (21.2) | 106 (33) |
