Fig. 7: Proposed model illustrating the orchestration of lipid-induced molecular changes. | npj Breast Cancer

Fig. 7: Proposed model illustrating the orchestration of lipid-induced molecular changes.

From: Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer

Fig. 7

Sensors: Senses the fatty acid-rich environment and perturb cellular metabolism providing the essential substrate for histone modifications and thereby turning on the Mediators- histone PTMs, which consequently activates the Effectors- Notch, adenylate cyclase, and MAPK-ERK the key protein signaling associated with ER− breast cancer.

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